The novel coronavirus disease 2019 (COVID-19) pandemic has spread worldwide, and
finding a safe therapeutic strategy and effective vaccine is critical to overcoming severe …

Diffuse midline glioma (DMG), formerly called diffuse intrinsic pontine glioma (DIPG), is a
high-grade malignant pediatric brain tumor with a near-zero survival rate. To date, only …

Found in all organisms, pyruvate dehydrogenase complexes (PDC) are the keystones of
prokaryotic and eukaryotic energy metabolism. In eukaryotic organisms these multi …

Simple Summary Despite a substantial increase in publications in recent years, liquid biopsy
from blood, cerebrospinal fluid (CSF), and other body fluids is usually not routinely used in …

Increasing evidence suggests that besides mutational and molecular alterations, the
immune component of the tumor microenvironment also substantially impacts tumor …

Brain tumors and brain metastases induce changes in brain tissue remodeling that lead to
immunosuppression and trigger an inflammatory response within the tumor …

Glioblastoma is an aggressive primary brain tumor that has seen few advances in treatments
for over 20 years. In response to this desperate clinical need, multiple immunotherapy …

Behçet's syndrome (BS) is a systemic vasculitis with several clinical manifestations.
Neutrophil hyperactivation mediates vascular BS pathogenesis, via both a massive reactive …

Bradykinin is a small active peptide and is considered an inflammatory mediator in several
pathological conditions. Bradykinin exerts its effects by coupling to its receptors, including …

Glioblastoma (GBM) is a highly aggressive primary brain tumor that is largely refractory to
treatment and, therefore, invariably relapses. GBM patients have a median overall survival of …