Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …

Pancreatic islet transplantation has become an established approach to β-cell replacement
therapy for the treatment of insulin-deficient diabetes. Recent progress in techniques for islet …

SARS-CoV-2 has caused the COVID-19 pandemic. There is an urgent need for
physiological models to study SARS-CoV-2 infection using human disease-relevant cells …

Recent clinical data have suggested a correlation between coronavirus disease 2019
(COVID-19) and diabetes. Here, we describe the detection of SARS-CoV-2 viral antigen in …

Transplantation of stem cell–derived β (SC-β) cells represents a promising therapy for type 1
diabetes (T1D). However, the delivery, maintenance, and retrieval of these cells remain a …

Type 1 diabetes (T1D) results from destruction of pancreatic beta cells by T cells of the
immune system. Despite improvements in insulin analogs and continuous blood glucose …

Pancreatic islet transplantation can cure diabetes but requires accessible, high-quality islets
in sufficient quantities. Cryopreservation could solve islet supply chain challenges by …

The main goal of treatment for type 1 diabetes is to control glycaemia with insulin therapy to
reduce disease complications. For some patients, technological approaches to insulin …

Three-dimensional (3D) multicellular organoids recapitulate the native complexities of
human tissue better than traditional cellular monolayers. As organoids are insufficiently …

This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …