Obesity leads to chronic, systemic inflammation and can lead to insulin resistance (IR), β-cell
dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state …

Obesity is becoming an epidemic in the United States and worldwide and increases risk for
many diseases, particularly insulin resistance, type 2 diabetes mellitus, and cardiovascular …

Metabolic abnormalities such as dyslipidemia, hyperinsulinemia, or insulin resistance and
obesity play key roles in the induction and progression of type 2 diabetes mellitus (T2DM) …

Decades of research in skeletal muscle physiology have provided multiscale insights into
the structural and functional complexity of this important anatomical tissue, designed to …

As the principal tissue for insulin-stimulated glucose disposal, skeletal muscle is a primary
driver of whole-body glycemic control. Skeletal muscle also uniquely responds to muscle …

Obesity is the most common cause of insulin resistance, and the current obesity epidemic is
driving a parallel rise in the incidence of T2DM. It is now widely recognized that chronic …

Obesity is associated with chronic inflammation, which contributes to insulin resistance and
type 2 diabetes mellitus. Under normal conditions, skeletal muscle is responsible for the …

The worldwide obesity epidemic has emerged as a major cause of insulin resistance and
Type 2 diabetes. Chronic tissue inflammation is a well-recognized feature of obesity, and the …

Inflammation can arise in response to a variety of stimuli, including infectious agents, tissue
injury, autoimmune diseases, and obesity. Some of these responses are acute and resolve …

Obesity and type 2 diabetes mellitus (T2DM) are increasing in prevalence owing to
decreases in physical activity levels and a shift to diets that include addictive and/or high …