Neutrophils are the frontline cells in response to microbial infections and are involved in a
range of inflammatory disorders in the body. In recent years, neutrophils have gained …

Immune checkpoint inhibitor (ICI) activates host's anti-tumor immune response by blocking
negative regulatory immune signals. A series of clinical trials showed that ICI could …

microRNAs (miRNAs) are small non-coding RNA molecules, evolutionary conserved. They
target more than one mRNAs, thus influencing multiple molecular pathways, but also …

Angiogenesis plays a critical role within the human body, from the early stages of life (ie,
embryonic development) to life-threatening diseases (eg, cancer, heart attack, stroke, wound …

Cancer is a complex disease, and its study requires deep understanding of several
biological processes and their regulation. It is an accepted fact that non-coding RNAs are …

Abstract CD133 (prominin-1), a pentaspan membrane glycoprotein, is one of the most well-
characterized biomarkers used for the isolation of cancer stem cells (CSCs). The presence …

The vascular endothelial growth factor receptor-1 (VEGFR-1) is a tyrosine kinase receptor
for VEGF-A, VEGF-B, and placental growth factor (PlGF) ligands that is expressed in …

Angiogenesis, formation of new blood vessels from the existing vascular network, is a
hallmark of cancer cells that leads to tumor vascular proliferation and metastasis. This …

Diabetic retinopathy (DR) is one of the leading causes of visual impairment in the working-
age population. DR is a progressive eye disease caused by long-term accumulation of …

Remarkable advances in nano delivery systems have provided new hope for tumor
prevention, diagnosis and treatment. However, only limited clinical therapeutic effects …