Decades of research in skeletal muscle physiology have provided multiscale insights into
the structural and functional complexity of this important anatomical tissue, designed to …

With the reignited push for manned spaceflight and the development of companies focused
on commercializing spaceflight, increased human ventures into space are inevitable …

The COVID-19 pandemic has had a devastating global impact, with older adults being most
at risk of death from the disease. However, acute sarcopenia occurs in survivors of COVID …

Skeletal muscle is one of the most abundant and highly plastic tissues. The ubiquitin–
proteasome system (UPS) is recognised as a major intracellular protein degradation system …

Prolonged periods of skeletal muscle inactivity or mechanical unloading (bed rest, hindlimb
unloading, immobilization, spaceflight and reduced step) can result in a significant loss of …

Exercise training is one of the most effective interventional strategies for sarcopenia in aged
people. Nevertheless, the underlying mechanisms are not well recognized. Increasing …

The ubiquitin–proteasome system (UPS) is the main regulatory mechanism of protein
degradation in skeletal muscle. The ubiquitin-ligase enzymes (E3s) have a central role in …

There has been increasing interest and research into sarcopenia in community-dwelling
older adults since the European Working Group on Sarcopenia in Older People (EWGSOP) …

While sarcopenia and sarcopenic obesity have been recognized in the last decade, a
combined concept to include decreased muscle mass and strength, as well as decreased …

Skeletal muscle atrophy, referred to as sarcopenia, is often observed in chronic kidney
disease (CKD) patients, especially in patients who are undergoing hemodialysis. The …