The etiology of endemic rickets was discovered a century ago. Vitamin D is the precursor of
25-hydroxyvitamin D and other metabolites, including 1, 25 (OH) 2D, the ligand for the …

Background A large number of observational studies have reported harmful effects of low 25-
hydroxyvitamin D (25OHD) levels on non-skeletal outcomes. We performed a systematic …

Objective To evaluate the breadth, validity, and presence of biases of the associations of
vitamin D with diverse outcomes. Design Umbrella review of the evidence across systematic …

Vitamin D deficiency, which classically manifests as bone disease (either rickets or
osteomalacia), is characterized by impaired bone mineralization. More recently, the term …

Observational studies, randomized controlled trials (RCTs), and Mendelian randomization
(MR) studies have yielded inconsistent results on the associations of vitamin D …

Rickets in children and osteomalacia in adults are the classic manifestations of profound
vitamin D deficiency. In recent years, however, non-musculoskeletal conditions—including …

Epidemiological studies have suggested a reduced risk of several cancers associated with
high vitamin D status. We performed a systematic review with meta‐analyses of …

The vitamin D receptor (VDR) is found in nearly all, if not all, cells in the body. The enzyme
that produces the active metabolite of vitamin D and ligand for VDR, namely CYP27B1 …

The relationship between vitamin D and breast cancer is still controversial. The present meta-
analysis examines the effects of the 25 (OH) D, 1, 25 (OH) 2D and vitamin D intake on breast …

Introduction: Many studies have been published, but none have pooled the useful evidence
available in the literature to produce guidelines and health policies promoting healthy eating …