Insights from preclinical choice models on treating drug addiction
ML Banks, SS Negus - Trends in pharmacological sciences, 2017 - cell.com
Substance-use disorders are a global public health problem that arises from behavioral
misallocation between drug use and more adaptive behaviors maintained by nondrug …
misallocation between drug use and more adaptive behaviors maintained by nondrug …
Nucleus accumbens Drd1-expressing neurons control aggression self-administration and aggression seeking in mice
We recently developed a mouse model of appetitive operant aggression and reported that
adult male outbred CD-1 mice lever-press for the opportunity to attack subordinate male …
adult male outbred CD-1 mice lever-press for the opportunity to attack subordinate male …
Effect of the novel positive allosteric modulator of metabotropic glutamate receptor 2 AZD8529 on incubation of methamphetamine craving after prolonged voluntary …
Background Cue-induced methamphetamine craving increases after prolonged forced
(experimenter-imposed) abstinence from the drug (incubation of methamphetamine …
(experimenter-imposed) abstinence from the drug (incubation of methamphetamine …
Increased heroin intake and relapse vulnerability in intermittent relative to continuous self‐administration: sex differences in rats
Background and Purpose Studies using intermittent‐access drug self‐administration show
increased motivation to take and seek cocaine and fentanyl, relative to continuous access. In …
increased motivation to take and seek cocaine and fentanyl, relative to continuous access. In …
Non-pharmacological factors that determine drug use and addiction
Based on their pharmacological properties, psychoactive drugs are supposed to take control
of the natural reward system to finally drive compulsory drug seeking and consumption …
of the natural reward system to finally drive compulsory drug seeking and consumption …
Characterization of operant social interaction in rats: effects of access duration, effort, peer familiarity, housing conditions, and choice between social interaction vs …
JJ Chow, NJ Beacher, JM Chabot, M Oke… - …, 2022 - Springer
Rationale and objective Social factors play a critical role in drug addiction. We recently
showed that rats will abstain from methamphetamine, cocaine, heroin, and remifentanil self …
showed that rats will abstain from methamphetamine, cocaine, heroin, and remifentanil self …
Compulsive addiction-like aggressive behavior in mice
Background Some people are highly motivated to seek aggressive encounters, and among
those who have been incarcerated for such behavior, recidivism rates are high. These …
those who have been incarcerated for such behavior, recidivism rates are high. These …
A common limiter circuit for opioid choice and relapse identified in a rodent addiction model
JA Heinsbroek, G Giannotti, MR Mandel… - Nature …, 2021 - nature.com
Activity in numerous brain regions drives heroin seeking, but no circuits that limit heroin
seeking have been identified. Furthermore, the neural circuits controlling opioid choice are …
seeking have been identified. Furthermore, the neural circuits controlling opioid choice are …
Modeling the development of drug addiction in male and female animals
WJ Lynch - Pharmacology Biochemistry and Behavior, 2018 - Elsevier
An increasing emphasis has been placed on the development and use of animal models of
addiction that capture defining features of human drug addiction, including escalation/binge …
addiction that capture defining features of human drug addiction, including escalation/binge …
Trying to make sense of rodents' drug choice behavior
SH Ahmed - Progress in Neuro-Psychopharmacology and …, 2018 - Elsevier
Since the first experimental hint for the existence of “an actual desire or striving for the drug”
in nonhuman animals by Sidney Spragg in the late 1930s, much effort has been expended …
in nonhuman animals by Sidney Spragg in the late 1930s, much effort has been expended …