Effects of alcohol dependence on discrete choice between alcohol and saccharin

M Russo, D Funk, A Loughlin, K Coen… - …, 2018 - nature.com
Dependence on drugs has enduring effects on drug intake and relapse. The role of choice in
enhanced susceptibility to drug use in drug dependence has been little studied. Here we …

Maternal diet influences the reinstatement of cocaine-seeking behavior and the expression of melanocortin-4 receptors in female offspring of rats

D Gawliński, K Gawlińska, M Frankowska, M Filip - Nutrients, 2020 - mdpi.com
Recent studies have emphasized the role of the maternal diet in the development of mental
disorders in offspring. Substance use disorder is a major global health and economic …

Random access to palatable food stimulates similar addiction-like responses as a fixed schedule, but only a fixed schedule elicits anticipatory activation

G Muñoz-Escobar, NN Guerrero-Vargas, C Escobar - Scientific reports, 2019 - nature.com
Restricted intermittent food access to palatable food (PF) induces addiction-like behaviors
and plastic changes in corticolimbic brain areas. Intermittent access protocols normally …

'Waiting impulsivity'in isolation-reared and socially-reared rats: effects of amphetamine

YP Liu, LS Wilkinson, TW Robbins - Psychopharmacology, 2017 - Springer
Background Rats reared in social isolation exhibit various cognitive and behavioural
abnormalities in adulthood. However, impulsivity following this treatment still remains …

Post-retrieval extinction prevents reconsolidation of methamphetamine memory traces and subsequent reinstatement of methamphetamine seeking

YY Chen, LB Zhang, Y Li, SQ Meng… - Frontiers in molecular …, 2019 - frontiersin.org
Methamphetamine abuse has become a serious public health problem. However, effective
treatment for methamphetamine addiction remains elusive, especially considering its high …

Pre-trial cocaine biases choice toward cocaine through suppression of the nondrug option

L Freese, A Durand, K Guillem, SH Ahmed - … Biochemistry and Behavior, 2018 - Elsevier
Being under the influence during choice between drug and nondrug options can have a
dramatic effect on choice outcomes. When rats face a choice between cocaine and sweet …

Misdeed of the need: towards computational accounts of transition to addiction

M Keramati, SH Ahmed, BS Gutkin - Current opinion in neurobiology, 2017 - Elsevier
Highlights•Reinforcement learning models link dopamine to acquisition of drug-oriented
behaviors.•Recent computational theory completes them by adding goal hierarchy and …

Effects of environmental manipulations and treatment with bupropion and risperidone on choice between methamphetamine and food in rhesus monkeys

ML Banks, BE Blough - Neuropsychopharmacology, 2015 - nature.com
Preclinical and human laboratory choice procedures have been invaluable in improving our
knowledge of the neurobiological mechanisms of drug reinforcement and in the drug …

Abstinence environment contributes to age differences in reinstatement of cocaine seeking between adolescent and adult male rats

C Li, KJ Frantz - Pharmacology Biochemistry and Behavior, 2017 - Elsevier
Abstracts Rationale Extinction responding and cue-induced reinstatement of cocaine
seeking after 60-days of forced abstinence are attenuated in male rats that self-administered …

Altered body weight associated with substance abuse: a look beyond food intake

R Crossin, AJ Lawrence, ZB Andrews… - Addiction Research & …, 2019 - Taylor & Francis
Background: Substance abuse can cause a range of harmful secondary health
consequences, including body weight changes. These remain poorly understood but can …