Substance use disorders are diagnosed as a manifestation of inappropriate behavioral
allocation toward abused drugs and away from other behaviors maintained by more …

Recent studies show that emotional and environmental stimuli promote epigenetic
inheritance and influence behavioral development in the subsequent generations. Caloric …

Understanding the mechanisms underpinning individual variance in addiction vulnerability
requires the development of validated, high-throughput screens. In a prior study of a large …

Are individuals suffering from addiction in control of their drug use behavior, and is this
control habitual or goal-directed? The habit theory of addiction posits that compulsion and …

Background Cue-induced methamphetamine craving increases after prolonged forced
(experimenter-imposed) abstinence from the drug (incubation of methamphetamine …

Background Methamphetamine addiction is a significant public health problem for which no
Food and Drug Administration-approved pharmacotherapies exist. Preclinical drug vs. food …

Rationale Cocaine use not only depends on the reinforcing properties of the drug, but also
on its pharmacological effects on alternative nondrug activities. In animal models …

Delineating the decision-making mechanisms underlying choice between drug and nondrug
rewards remains a challenge. This study adopts an original approach to probe these …

Cue reactivity is the maladaptive neurobiological and behavioral response upon exposure
to drug cues and is a major driver of relapse. The leading hypothesis is that dopamine …

Methamphetamine is a potent psychostimulant with high abuse rates. Currently, there is no
Food and Drug Administration-approved pharmacotherapy for methamphetamine addiction …