In the first 20 years that followed the purinergic signalling hypothesis in 1972, most scientists
were sceptical about its validity, largely because ATP was so well established as an …

Since the discovery of the endogenous opioid peptides (H ughes et al. 1975b), our
understanding of the mode of action of opioids has advanced rapidly. It is now known that in …

Previous pharmacological studies have indicated the possible existence of functional
interactions between μ-, δ-and κ-opioid receptors in the CNS. We have investigated this …

Enkephalin is compared to morphine and its congeners with particular regard to physico-
chemical properties, biological stability and sensitivity to narcotic antagonists. Possible sites …

The discovery in the 1970s of endogenous opioid peptides including the enkephalins, H-Tyr-
Gly-Gly-Phe-Met-OH ([Meplenkephalin)(1) and H-Tyr-Gly-Gly-Phe-Leu-OH ([Leus] …

1 The activity pattern of analogues of the enkephalins was determined in four parallel
assays, the inhibition of the electrically evoked contraction of the guinea‐pig ileum and …

1.1. 1.2. Cervical ganglion 1.1. 1.3. Neuromuscular junction 1.1. 1.4. Cerebral cortex 1.1. 1.5.
Striatum 1.1. 2. Neuro-effector transmission 1.1. 3. Physiological role and clinical …

ABSTRACT Tripathi, Hem L., Billy R. Martin and Mario D. Aceto: Nicotineinduced
antinociception in rats and mice: Correlation with nicotine brain levels. J. Pharmacol. Exp …

Competition and cooperation are thought to represent the opposite extremes of organism
interactions. I here show that the formation of aggregations in a sessile organism requires …

[Phe1Ψ (CH2‐NH) Gly2] NC (1‐13) NH2 has been tested in the electrically stimulated
guinea pig ileum and mouse vas deferens, two nociceptin sensitive preparations. The new …