The psychoactive cannabinoids (-)-delta 9-tetrahydrocannabinol ((-)-delta 9-THC) and the 1,
1-dimethyl-heptyl homologue of (-)-11-hydroxy-delta 8-tetrahydrocannabinol ((-)-DMH) both …

7-Hydroxymitragynine, a constituent of the Thai herbal medicine Mitragyna speciosa, has
been found to have a potent opioid antinociceptive effect. In the present study, we …

In 1969 Reynolds reported that electrical stimulation of the meaencephalic central gray
matter produced sufficient analgesia to allow surgery in rate (1). Subsequently, reports from …

Opioid and opioid-like receptors are activated by a variety of endogenous peptides including
[Met] enkephalin (met),[Leu] enkephalin (leu), β-endorphin (β-end), α-neodynorphin …

A series of six synthetic octapeptides, structurally related to somatostatin, demonstrate high
affinity and selectivity for mu opioid receptors in radioligand binding assays. The …

The newly discovered neuropeptide, nociceptin (alias orphanin FQ), was tested for its
potential direct effects, as well as for its ability to modify the electrically evoked contractions …

1 The endogenous opioid ligands interact with more than one of the μ‐, δ‐and κ‐binding
sites. By the use of binding assays and bioassays, enkephalin analogues have been …

The carotid body type I cell contains amines1–3 and has features, both morphological and
cytochemical, which indicate that it may also produce a peptide4–6. Many regulatory …

The synthesis of four enkephalinamide analogs is described in which the peptide bond
between residues 4 and 5 is reversed with or without simultaneous reversal of the carboxyl …

In the guinea-pig ileum methionine-enkephalin, normophine and morphine are equipotent in
depressing electrically evoked contractions; leucine-enkephalin has about 25% of the …