It is with deep gratitude that I receive the honour of having been selected by the Trustees of
the Gaddum Memorial Fund to deliver the Sixth Gaddum Memorial Lecture. Among many …

A search was performed for presynaptic, release-modulating receptor systems on the
postganglionic sympathetic nerves of rabbit pulmonary artery. Strips of the artery were …

The brain peptide Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH 2) was tested for its effects on electrically
stimulated contractions in the guinea pig ileum assay. Tyr-MIF-1 acted as an opiate agonist …

The vas deferens has been used as a model for many diverse studies of different aspects of
autonomic neurotransmission since its introduction including, in particular, sympathetic …

A new class of endomorphin-1 (EM-1) analogues were synthesized by introduction of novel
unnatural α-methylene-β-amino acids (Map) at position 3 or/and position 4. Their binding …

The electrically‐evoked contractions of the rat vas deferens were selectively inhibited by β‐
endorphin, the preparation being much less sensitive to enkephalins and narcotic analgesic …

The mantis shrimp Squilla mantis responds to an electrical shock with a quick and violent
flexure of its body (Fig. 1 and 2). The reaction time of this defensive response was measured …

The enkephalin analogs,[D-Pen 2, L-Cys 5]-and [D-Pen 2, D-Cys 5]-enkephalin are cyclic
compounds, conformationally constrained by virtue of their 14-membered, disulfide …

Various proenkephalin-derived peptides such as peptide E and the bovine adrenal medulla
peptides BAM-12P and BAM-22P are potent competitors on mu and kappa binding sites in …

Certain endogenous opioid peptides, which structurally resemble potential enkephalin
precursors (pro-enkephalins), were tested for their interaction with μ-, δ-and κ-type of opiate …