Amyloid precursor protein (APP) gives rise to the amyloid-β peptide and thus has a key role
in the pathogenesis of Alzheimer disease. By contrast, the physiological functions of APP …

For 20 years the amyloid cascade hypothesis of Alzheimer disease (AD) has placed the
amyloid-β peptide (Aβ), formed from the amyloid precursor protein (APP), centre stage in the …

Proteolysis of the amyloid precursor protein (APP) liberates various fragments including the
proposed initiator of Alzheimer disease-associated dysfunctions, amyloid-β. However …

Compelling genetic evidence links the amyloid precursor protein (APP) to Alzheimer's
disease (AD) and several theories have been advanced to explain the relationship. A …

Amyloid precursor protein (APP) and its metabolites play a key role in Alzheimer's disease
pathogenesis. The idea that APP may function as a receptor has gained momentum based …

Synaptic loss is the best correlate of cognitive deficits in Alzheimer's disease (AD). Extensive
experimental evidence also indicates alterations of synaptic properties at the early stages of …

Despite its key role in the molecular pathology of Alzheimer's disease (AD), the
physiological function of amyloid precursor protein (APP) is unknown. Increasing evidence …

Alzheimer's disease (AD) is the most common neurodegenerative disease with tens of
millions of people affected worldwide. The pathogenesis is still poorly understood and …

In Alzheimer's disease (AD), the distribution of the amyloid precursor protein (APP) and its
fragments other than amyloid beta, has not been fully characterized. Here, we investigate …

The amyloid precursor protein (APP), whose mutations cause familial Alzheimer's disease,
interacts with the synaptic release machinery, suggesting a role in neurotransmission. Here …