The endocannabinoid system, a new gatekeeper in the pharmacology of human hepatocellular carcinoma

N Ebrahimi, NP Far, SS Fakhr, F Faghihkhorasani… - Environmental …, 2023 - Elsevier
Despite numerous prevention methodologies and treatment options, hepatocellular
carcinoma (HCC) still remains as the third leading life-threatening cancer. It is thus pertinent …

Cannabinoid receptor activation potential of the next generation, generic ban evading OXIZID synthetic cannabinoid receptor agonists

MH Deventer, K Van Uytfanghe… - Drug Testing and …, 2022 - Wiley Online Library
In recent years, several nations have implemented various measures to control the surge of
new synthetic cannabinoid receptor agonists (SCRAs) entering the recreational drug market …

Excretion and residue depletion of cannabinoids in beef cattle fed hempseed cake for 111 days

DJ Smith, EM Serum, TM Winders… - Food Additives & …, 2023 - Taylor & Francis
Thirty-two crossbred heifers were fed either a control diet or 20%(dry matter basis)
hempseed cake in a complete ration for 111 days; of the cattle fed hempseed cake, four …

Encapsulation of Hemp (Cannabis sativa L.) Essential Oils into Nanoemulsions for Potential Therapeutic Applications: Assessment of Cytotoxicological Profiles

C Aguzzi, DR Perinelli, M Cespi, L Zeppa, E Mazzara… - Molecules, 2023 - mdpi.com
Industrial hemp (Cannabis sativa L.), due to its bioactive compounds (terpenes and
cannabinoids), has gained increasing interest in different fields, including for medical …

In vitro cannabinoid activity profiling of generic ban‐evading brominated synthetic cannabinoid receptor agonists and their analogs

MH Deventer, M Persson, C Norman… - Drug Testing and …, 2024 - Wiley Online Library
Following the enactment of a generic ban in China in 2021, the synthetic cannabinoid
market has been evolving, now encompassing even wider structural diversity. Compounds …

Potential perioperative cardiovascular outcomes in cannabis/cannabinoid users. A call for caution

M Echeverria-Villalobos, Y Guevara… - Frontiers in …, 2024 - frontiersin.org
Background Cannabis is one of the most widely used psychoactive substances. Its
components act through several pathways, producing a myriad of side effects, of which …

[HTML][HTML] Investigating selectivity and bias for G protein subtypes and β-arrestins by synthetic cannabinoid receptor agonists at the cannabinoid CB1 receptor

B Ryalls, M Patel, E Sparkes, SD Banister… - Biochemical …, 2024 - Elsevier
The cannabinoid CB 1 receptor (CB 1) is a G protein-coupled receptor (GPCR) with
widespread expression in the central nervous system. This canonically G⍺ i/o-coupled …

Fatal overdose with the cannabinoid receptor agonists MDMB-4en-PINACA and 4F-ABUTINACA: a case report and review of the literature

G Simon, M Kuzma, M Mayer, K Petrus, D Tóth - Toxics, 2023 - mdpi.com
A case of a 26-year-old male who died from consuming synthetic cannabinoid receptor
agonists MDMB-4en-PINACA and 4F-ABUTINACA is reported. MDMB-4en-PINACA and 4F …

Identification of novel cannabinoid CB2 receptor agonists from botanical compounds and preliminary evaluation of their anti-osteoporotic effects

SJ Hu, G Cheng, H Zhou, Q Zhang, QL Zhang, Y Wang… - Molecules, 2022 - mdpi.com
As cannabinoid CB2 receptors (CB2R) possess various pharmacological effects—including
anti-epilepsy, analgesia, anti-inflammation, anti-fibrosis, and regulation of bone metabolism …

Generation of High-Affinity Aptamers for Indazole Synthetic Cannabinoids

J Canoura, T Nguyen, C Byrd, R Hill, Y Liu… - Analytical …, 2024 - ACS Publications
Synthetic cannabinoids are a widely abused class of dangerous psychoactive substances,
especially among youths and young adults. Dozens of such drugs have been identified to …