Chronic, pathological pain remains a global health problem and a challenge to basic and
clinical sciences. A major obstacle to preventing, treating, or reverting chronic pain has been …

The sensory, associative and limbic neocortical structures play a critical role in shaping
incoming noxious inputs to generate variable pain perceptions. Technological advances in …

Chronic pain is a complex neuropsychiatric disorder characterized by sensory, cognitive,
and affective symptoms. Over the past 2 decades, researchers have made significant …

Chronic pain patients frequently develop and suffer from mental comorbidities such as
depressive mood, impaired cognition, and other significant constraints of daily life, which …

Neuropathic pain is a pathological condition induced by a lesion or disease affecting the
somatosensory system, with symptoms like allodynia and hyperalgesia. It has a multifaceted …

Pain is an integrated sensory and affective experience. Cortical mechanisms of sensory and
affective integration, however, remain poorly defined. Here, we investigate the projection …

Neurons in the prefrontal cortex (PFC) can provide top-down regulation of sensory-affective
experiences such as pain. Bottom-up modulation of sensory coding in the PFC, however …

Chronic pain patients often develop mental disorders, and anxiety disorders are common.
We hypothesize that the comorbid anxiety results from an imbalance between the reward …

The development of physical dependence and addiction disorders due to misuse of opioid
analgesics is a major concern with pain therapeutics. We developed a mouse model of …

Dopamine and its receptors are currently recognized targets for the treatment of several
neuropsychiatric disorders, including Parkinson's disease, schizophrenia, some drug use …