Since no approved therapies to restore mobility and sensation following spinal cord injury
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …

ABSTRACT A long-standing goal of spinal cord injury research is to develop effective spinal
cord repair strategies for the clinic. Rat models of spinal cord injury provide an important …

Central nervous system (CNS) injury transforms naive astrocytes into reactive astrocytes,
which eventually become scar-forming astrocytes that can impair axonal regeneration and …

Recovery from spinal cord injury (SCI) remains an unsolved problem. As a major component
of the SCI lesion, the glial scar is primarily composed of scar-forming astrocytes and plays a …

Severe spinal cord injury causes permanent loss of function and sensation throughout the
body. The trauma causes a multifaceted torrent of pathophysiological processes which …

Nerve regeneration in adult mammalian spinal cord is poor because of the lack of intrinsic
regeneration of neurons and extrinsic factors–the glial scar is triggered by injury and inhibits …

Many studies, using pre-clinical models of SCI, have demonstrated the efficacy of
chondroitinase ABC as a treatment for spinal cord injury and this has been confirmed in …

Spinal cord injury (SCI) triggers complex inflammatory and pathological processes that
ultimately lead to scar formation, thus resulting in the severe and irreversible loss of function …

Background Neuropathic pain triggered by peripheral nerve lesion is extremely difficult to
manage with current approaches, hence the importance of exploring therapeutic …

Background Spinal cord injury (SCI) results in glial scar formation and irreversible neuronal
loss, which finally leads to functional impairments and long-term disability. Our previous …