Tyrosine kinases are implicated in tumorigenesis and progression, and have emerged as
major targets for drug discovery. Tyrosine kinase inhibitors (TKIs) inhibit corresponding …

Elevated circulating insulin levels are frequently observed in the setting of obesity and early
type 2 diabetes, as a result of insensitivity of metabolic tissues to the effects of insulin. Higher …

Breast cancer affects approximately 1 in 8 women, and it is estimated that over 246,660
women in the USA will be diagnosed with breast cancer in 2016. Breast cancer mortality has …

Exciting therapeutic targets are emerging from CRISPR-based screens of high mutational-
burden adult cancers. A key question, however, is whether functional genomic approaches …

Successful drug discovery is like finding oases of safety and efficacy in chemical and
biological deserts. Screens in disease models, and other decision tools used in drug …

The insulin like growth factor (IGF) axis plays a fundamental role in normal growth and
development, and when deregulated makes an important contribution to disease. Here, we …

Purpose Type 2 diabetes mellitus (T2DM) is becoming increasingly prevalent worldwide.
Epidemiologic data suggest that T2DM is associated with an increased incidence and …

Importance The development of oncology drugs is expensive and beset by a high attrition
rate. Analysis of the costs and causes of translational failure may help to reduce attrition and …

Chemoresistance in pancreatic cancer cells may be caused by the expansion of inherently
resistant cancer cells or by the adaptive plasticity of initially sensitive cancer cells. We …

The insulin-like growth factor-I (IGF-I) signaling induces epithelial to mesenchymal transition
(EMT) program and contributes to metastasis and drug resistance in several subtypes of …