Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review

G El-Saber Batiha, A Magdy Beshbishy, L G. Wasef… - Nutrients, 2020 - mdpi.com
Medicinal plants have been used from ancient times for human healthcare as in the form of
traditional medicines, spices, and other food components. Garlic (Allium sativum L.) is an …

Possible side effects of polyphenols and their interactions with medicines

A Duda-Chodak, T Tarko - Molecules, 2023 - mdpi.com
Polyphenols are an important component of plant-derived food with a wide spectrum of
beneficial effects on human health. For many years, they have aroused great interest …

[HTML][HTML] Phytochemicals of garlic: Promising candidates for cancer therapy

Y Zhang, X Liu, J Ruan, X Zhuang, X Zhang… - Biomedicine & …, 2020 - Elsevier
Of the numerous health benefits of garlic, the anticancer effect is probably the most
noticeable. Observations over the past years have shown that the consumption of garlic in …

Interactions between CYP3A4 and dietary polyphenols

L Basheer, Z Kerem - Oxidative medicine and cellular longevity, 2015 - Wiley Online Library
The human cytochrome P450 enzymes (P450s) catalyze oxidative reactions of a broad
spectrum of substrates and play a critical role in the metabolism of xenobiotics, such as …

[HTML][HTML] Pharmacotherapeutic potential of phytochemicals: Implications in cancer chemoprevention and future perspectives

V Kaur, M Kumar, A Kumar, K Kaur, VS Dhillon… - Biomedicine & …, 2018 - Elsevier
Cancer is a leading cause of disease burden throughout the world. Many cancers develop
as a result of exposure to both lifestyle and environmental factors that are potentially …

Enzyme activity of natural products on cytochrome P450

HL Zuo, HY Huang, YCD Lin, XX Cai, XJ Kong, DL Luo… - Molecules, 2022 - mdpi.com
Drug-metabolizing enzymes, particularly the cytochrome P450 (CYP450) monooxygenases,
play a pivotal role in pharmacokinetics. CYP450 enzymes can be affected by various …

Opportunities and challenges in managing antibiotic resistance in bacteria using plant secondary metabolites

B Kongkham, D Prabakaran, H Puttaswamy - Fitoterapia, 2020 - Elsevier
Abstract Development of antibiotic resistance (ABR) in bacteria and its multidimensional
spread is an emerging global threat that needs immediate attention. Extensive antibiotics …

The role of myrrh metabolites in cancer, inflammation, and wound healing: prospects for a multi-targeted drug therapy

RS Suliman, SS Alghamdi, R Ali, D Aljatli… - Pharmaceuticals, 2022 - mdpi.com
Background: Myrrh extract is a well-known medicinal plant with significant therapeutic
benefits attributed to the activity of its diverse metabolites. It has promising activity against …

Interaction between phytotherapy and oral anticancer agents: prospective study and literature review

AL Clairet, M Boiteux-Jurain, E Curtit, M Jeannin… - Medical Oncology, 2019 - Springer
Cancer is becoming more prevalent in elderly patient. Due to polypharmacy, older adults
with cancer are predisposed to drug-drug interactions. There is also an increasing interest in …

Inhibitory effects of flavonoids on P-glycoprotein in vitro and in vivo: Food/herb-drug interactions and structure–activity relationships

J Bai, S Zhao, X Fan, Y Chen, X Zou, M Hu… - Toxicology and applied …, 2019 - Elsevier
Flavonoids are a class of polyphenol antioxygen, despite various known biological activities
and therapeutic potential, scattered but not much is known about their interactions with drug …