Long-term viability of thick three-dimensional engineered tissue constructs is a major
challenge. Addressing it requires development of vessel-like network that will allow the …

Vascularization of engineered tissues in vitro and in vivo remains a key problem in
translation of engineered tissues to clinical practice. Growth factor signalling can be …

Oxygen is a potent modulator of cell function and wound repair in vivo. The lack of oxygen
(hypoxia) can create a potentially lethal environment and limit cellular respiration and …

Parylene-C, which is traditionally used to coat implantable devices, has emerged as a
promising material to generate miniaturized devices due to its unique mechanical properties …

In this chapter, the authors define central criteria and key constraints in scaffold design. We
then in turn review the current state-of-the-art in manufacturing techniques applied to …

This protocol describes how to form a 3D cell culture with explicit, endothelialized
microvessels. The approach leads to fully enclosed, perfusable vessels in a bioremodelable …

Driven by the increasing economic burden associated with bone injury and disease,
biomaterial development for bone repair represents the most active research area in the …

This article contains the collective views expressed at the second session of the workshop"
Tissue Engineering—The Next Generation,''which was devoted to the tools of tissue …

Organ loss and failure is one of the most critical issues facing the healthcare industry in
developed nations. The shortage of available organ donors has driven the growth and …

Although there have been extensive research efforts to create functional tissues and organs,
most successes in tissue engineering have been limited to avascular or thin tissues. The …