Alpha‐kinase1 promotes tubular injury and interstitial inflammation in diabetic nephropathy by canonical pyroptosis pathway
X Cui, Y Li, S Yuan, Y Huang, X Chen, Y Han, Z Liu… - Biological Research, 2023 - Springer
Abstract Background Alpha‐kinase 1 (ALPK1) is a master regulator in inflammation and has
been proved to promote renal fibrosis by promoting the production of IL-1β in diabetic …
been proved to promote renal fibrosis by promoting the production of IL-1β in diabetic …
Masking of typical TLR4 and TLR5 ligands modulates inflammation and resolution by Helicobacter pylori
SK Pachathundikandi, N Tegtmeyer, S Backert - Trends in Microbiology, 2023 - cell.com
Helicobacter pylori is a paradigm of chronic bacterial infection and is associated with peptic
ulceration and malignancies. H. pylori uses specific masking mechanisms to avoid …
ulceration and malignancies. H. pylori uses specific masking mechanisms to avoid …
Know your neighbors: microbial recognition at the intestinal barrier and its implications for gut homeostasis and inflammatory bowel disease
K Iyer, L Erkert, C Becker - Frontiers in Cell and Developmental …, 2023 - frontiersin.org
Intestinal epithelial cells (IECs) perform several physiological and metabolic functions at the
epithelial barrier. IECs also play an important role in defining the overall immune functions at …
epithelial barrier. IECs also play an important role in defining the overall immune functions at …
Innate immunity in allergy
K Maeda, MJ Caldez, S Akira - Allergy, 2019 - Wiley Online Library
Innate immune system quickly responds to invasion of microbes and foreign substances
through the extracellular and intracellular sensing receptors, which recognize distinctive …
through the extracellular and intracellular sensing receptors, which recognize distinctive …
Mechanisms of persistence, innate immune activation and immunomodulation by the gastric pathogen Helicobacter pylori
X Zhang, IC Arnold, A Müller - Current opinion in microbiology, 2020 - Elsevier
The gastric bacterium Helicobacter pylori efficiently evades innate immune detection and
persistently colonizes its human host. Understanding the genetic determinants that H. pylori …
persistently colonizes its human host. Understanding the genetic determinants that H. pylori …
In vitro and ex vivo modeling of enteric bacterial infections
Enteric bacterial infections contribute substantially to global disease burden and mortality,
particularly in the developing world. In vitro 2D monolayer cultures have provided critical …
particularly in the developing world. In vitro 2D monolayer cultures have provided critical …
Improving mass spectrometry analysis of protein structures with arginine-selective chemical cross-linkers
Chemical cross-linking of proteins coupled with mass spectrometry analysis (CXMS) is
widely used to study protein-protein interactions (PPI), protein structures, and even protein …
widely used to study protein-protein interactions (PPI), protein structures, and even protein …
The role of microbiota-derived metabolites in colorectal cancer
C Duizer, MR de Zoete - International Journal of Molecular Sciences, 2023 - mdpi.com
The impact of bacterial members of the microbiota on the development of colorectal cancer
(CRC) has become clear in recent years. However, exactly how bacteria contribute to the …
(CRC) has become clear in recent years. However, exactly how bacteria contribute to the …
Infection infidelities drive innate immunity
JC Kagan - Science, 2023 - science.org
Within multicellular organisms, innate immune pattern recognition receptors (PRRs) control
host defenses to infection. These receptors are activated by microbes, which facilitate their …
host defenses to infection. These receptors are activated by microbes, which facilitate their …
ALPK1 Aggravates TMJOA cartilage degradation via NF-κB and ERK1/2 signaling
X Liu, J Zhao, H Jiang, H Li, Y Feng… - Journal of Dental …, 2022 - journals.sagepub.com
Temporomandibular joint osteoarthritis (TMJOA) is a common degenerative joint disease
without effective intervention strategies. Previous research implied that alpha-kinase 1 …
without effective intervention strategies. Previous research implied that alpha-kinase 1 …