Abstract Background Alpha‐kinase 1 (ALPK1) is a master regulator in inflammation and has
been proved to promote renal fibrosis by promoting the production of IL-1β in diabetic …

Helicobacter pylori is a paradigm of chronic bacterial infection and is associated with peptic
ulceration and malignancies. H. pylori uses specific masking mechanisms to avoid …

Intestinal epithelial cells (IECs) perform several physiological and metabolic functions at the
epithelial barrier. IECs also play an important role in defining the overall immune functions at …

Innate immune system quickly responds to invasion of microbes and foreign substances
through the extracellular and intracellular sensing receptors, which recognize distinctive …

The gastric bacterium Helicobacter pylori efficiently evades innate immune detection and
persistently colonizes its human host. Understanding the genetic determinants that H. pylori …

Enteric bacterial infections contribute substantially to global disease burden and mortality,
particularly in the developing world. In vitro 2D monolayer cultures have provided critical …

Chemical cross-linking of proteins coupled with mass spectrometry analysis (CXMS) is
widely used to study protein-protein interactions (PPI), protein structures, and even protein …

The impact of bacterial members of the microbiota on the development of colorectal cancer
(CRC) has become clear in recent years. However, exactly how bacteria contribute to the …

Within multicellular organisms, innate immune pattern recognition receptors (PRRs) control
host defenses to infection. These receptors are activated by microbes, which facilitate their …

Temporomandibular joint osteoarthritis (TMJOA) is a common degenerative joint disease
without effective intervention strategies. Previous research implied that alpha-kinase 1 …