The Gram-negative bacterium Campylobacter jejuni is a major cause of foodborne disease
in humans. After infection, C. jejuni rapidly colonizes the mucus layer of the small and large …

While largely neglected over decades during which adaptive immunity captured most of the
attention, innate immune mechanisms have now become central to our understanding of …

Inflammatory bowel disease (IBD) are heterogenous disorders of the gastrointestinal tract
caused by a spectrum of genetic and environmental factors. In mice, overlapping regions of …

Stimulator of interferon genes (STING) is an integral ER-membrane protein that can be
activated by 2′ 3′-cGAMP synthesized by cyclic guanosine monophosphate–adenosine …

Helicobacter pylori is the first bacterium formally recognized to play a causative role in
human malignancies, gastric cancer and gastric mucosa-associated lymphoid tissue (MALT) …

Microbial infections are sensed by the host immune system by recognizing signature
molecules called Pathogen-Associated Molecular Patterns—PAMPs. The binding of these …

Purpose We aimed to characterize the ocular phenotype of patients with ROSAH (retinal
dystrophy, optic nerve edema, splenomegaly, anhidrosis, and headache) syndrome and …

Helicobacter pylori strains can be broadly classified into two groups based on whether they
contain or lack a chromosomal region known as the cag pathogenicity island (cag PAI) …

The bacterial pathogen Listeria monocytogenes is well adapted to life in the soil and on
vegetation as a saprophyte (ie, extracellular environments) and to life in the cytosol of …

The human gastric pathogen Helicobacter pylori activates human epithelial cells by a
particular combination of mechanisms, including NOD1 and ALPK1-TIFA activation. These …