Klebsiella pneumoniae is a leading cause of Gram-negative bacteremia, which is a major
source of morbidity and mortality worldwide. Gram-negative bacteremia requires three major …

A hallmark of infection by the pathogen Helicobacter pylori, which colonizes the human
gastric epithelium, is the simultaneous activation of the classical and alternative nuclear …

Lipopolysaccharide inner core heptose metabolites, including ADP-heptose, play a
substantial role in the activation of cell-autonomous innate immune responses in eukaryotic …

Transcription factors of the nuclear factor kappa‐light‐chain‐enhancer of activated B cells
(NF-ĸB) family control important signaling pathways in the regulation of the host innate …

Microbial pathogens have evolved complex mechanisms to interface with host cells in order
to evade host defenses and replicate. However, mammalian innate immune receptors detect …

Protein phosphorylation is one of the most widespread post-translational modifications in
biology. With the advent of mass spectrometry-based phosphoproteomics, more than …

Background Activation of the nuclear factor B (NF-κB) signaling pathway by pattern
recognition receptors (PRRs) is regarded as a crucial mechanism of neuroinflammation and …

The atypical protein kinase ALPK1 is activated by the bacterial nucleotide sugar ADP-
heptose and phosphorylates TIFA to switch on a signaling pathway that combats microbial …

The microbiota have emerged as an important factor in host physiology, disease, and
response to therapy. These diverse microbes (bacteria, virus, fungi, and protists) encode …

Helicobacter pylori represents a highly successful colonizer of the human stomach.
Infections with this Gram-negative bacterium can persist lifelong, and although in the …