Helicobacter pylori represents a highly successful colonizer of the human stomach.
Infections with this Gram-negative bacterium can persist lifelong, and although in the …

The lipopolysaccharide O-antigen structure expressed by the European Helicobacter pylori
model strain G27 encompasses a trisaccharide, an intervening glucan-heptan and distal …

Helicobacter pylori infection is linked to serious gastric-related diseases including gastric
cancer. However, current therapies for treating H. pylori infection are challenged by the …

Heptose metabolites including ADP-d-glycero-β-d-manno-heptose (ADP-heptose) are
involved in bacterial lipopolysaccharide and cell envelope biosynthesis. Recently, heptoses …

Highlights•FHA domain-containing proteins are critical gatekeepers of diverse signaling
pathways.•TIFA and TIFAB are critical FHA domain-containing proteins in immune-sensing …

Nuclear factor κB (NF-κB) is activated by various inflammatory and infectious molecules and
is involved in immune responses. It has been elucidated that ADP-β-D-manno-heptose …

The human pathogen Helicobacter pylori interacts intimately with gastric epithelial cells to
induce inflammatory responses that are a hallmark of the infection. This inflammation is a …

PFAPA is an autoinflammatory syndrome characterized by periodic fever, aphthous
stomatitis, sterile pharingitis, and adenitis, with an onset usually before the age of five. While …

Obesity is associated with activation of low-grade inflammation in tissues metabolically
relevant for the regulation glucose homeostasis. The gut microbiota has been extensively …

Food availability and usage is a major adaptive force for the successful survival of animals in
nature, yet little is known about the specific signals that activate the host digestive system to …