Intimate Relations: Molecular and Immunologic Interactions Between Neisseria gonorrhoeae and HIV-1

F Guvenc, R Kaul, SD Gray-Owen - Frontiers in microbiology, 2020 - frontiersin.org
While the global incidence of human immunodeficiency virus (HIV-1) remains well above
UNAIDS targets, sexual transmission HIV is surprisingly inefficient. A variety of host, viral …

Taking microbiota into consideration in mesenchymal stem cell research

H Tu, E Xiao, O Liu - Journal of Dental Research, 2022 - journals.sagepub.com
Mesenchymal stem cells (MSCs) are a promising therapy in regenerative medicine, but the
clinical efficacy has yet to be identified, because the functions of MSCs are modulated by …

ADP‐heptose enables Helicobacter pylori to exploit macrophages as a survival niche by suppressing antigen‐presenting HLA‐II expression

S Coletta, G Battaggia, C Della Bella, M Furlani… - FEBS …, 2021 - Wiley Online Library
The persistence of Helicobacter pylori in the human gastric mucosa implies that the immune
response fails to clear the infection. We found that H. pylori compromises the antigen …

Recent Advances of Engineered Cell Membrane‐Based Nanotherapeutics to Combat Inflammatory Diseases

J Ma, L Ding, X Peng, L Jiang, G Liu - Small, 2024 - Wiley Online Library
An immune reaction known as inflammation serves as a shield from external danger signals,
but an overactive immune system may additionally lead to tissue damage and even a variety …

[HTML][HTML] Beyond the gastric epithelium—the paradox of Helicobacter pylori-induced immune responses

T Neuper, T Frauenlob, G Posselt… - Current Opinion in …, 2022 - Elsevier
Highlights•Recent advances identify two H. pylori proteins as novel TLR5 ligands.•ADP
heptose from H. pylori induces DNA damage in gastric epithelial cells.•Dendritic cells …

Helicobacter pylori virulence factors: subversion of host immune system and development of various clinical outcomes

R Mohammadzadeh, S Menbari… - Expert Reviews in …, 2023 - cambridge.org
Helicobacter pylori (H. pylori) is a worldwide spread bacterium, co-evolving with humans for
at least 100 000 years. Despite the uncertainty about the mode of H. pylori transmission, the …

In the age of viral pandemic, can ingredients inspired by human milk and infant nutrition be repurposed to support the immune system?

LR Brink, M Chichlowski, N Pastor… - Nutrients, 2021 - mdpi.com
In 2020, with the advent of a pandemic touching all aspects of global life, there is a renewed
interest in nutrition solutions to support the immune system. Infants are vulnerable to …

AI‐2 represses CagA expression and bacterial adhesion, attenuating the Helicobacter pylori‐induced inflammatory response of gastric epithelial cells

Y Wen, H Huang, T Tang, H Yang, X Wang… - …, 2021 - Wiley Online Library
Background Helicobacter pylori (H. pylori) infection of gastric epithelial cells induces
inflammatory response. Outer membrane proteins (OMPs), Type 4 secretion system (T4SS) …

Guardians of the cell: effector-triggered immunity steers mammalian immune defense

TA Kufer, EM Creagh, CE Bryant - Trends in Immunology, 2019 - cell.com
The mammalian innate immune system deals with invading pathogens and stress by
activating pattern-recognition receptors (PRRs) in the host. Initially proposed to be triggered …

[HTML][HTML] Ectopic expression of cGAS in Salmonella typhimurium enhances STING-mediated IFN-β response in human macrophages and dendritic cells

L Waanders, LEH van der Donk, LS Ates… - … for Immunotherapy of …, 2023 - ncbi.nlm.nih.gov
Background Interferon (IFN)-β induction via activation of the stimulator of interferon genes
(STING) pathway has shown promising results in tumor models. STING is activated by cyclic …