Diabetic kidney disease (DKD) remains the leading cause of end-stage renal disease
(ESRD) and is therefore a major burden on the healthcare system. Patients with DKD are …

ROCK belongs to the AGC family of Ser/Thr protein kinases that are involved in many
cellular processes. ROCK-driven actomyosin contractility regulates cytoskeletal dynamics …

Single-nucleotide polymorphisms in the gene encoding G protein-coupled receptor 35
(GPR35) are associated with increased risk of inflammatory bowel disease. However, the …

Diabetes is a worldwide health issue closely associated with cardiovascular events. Given
the pandemic of obesity, the identification of the basic underpinnings of vascular disease is …

Cancer immunotherapy is fast rising as a prominent new pillar of cancer treatment,
harnessing the immune system to fight against numerous types of cancer. Rho-kinase …

Traumatic brain injury (TBI) impairs the ability to restore homeostasis in response to stress,
indicating hypothalamic-pituitary-adrenal (HPA)-axis dysfunction. Many stressors result in …

Chronic graft-versus-host disease (cGVHD) is an immune-mediated disorder characterized
by chronic inflammation and fibrosis. Rho-associated coiled-coil–containing protein kinases …

In accordance with “the response to injury” theory, the entry of monocytes into the intima
guided by inflammation signals, taking up cholesterol and transforming into foam cells, and …

Severe COVID-19 is characterized by acute respiratory distress syndrome (ARDS)-like
hyperinflammation and endothelial dysfunction, that can lead to respiratory and multi organ …

Pulmonary hypertension (PH) is a cardiovascular disease caused by extensive vascular
remodeling in the lungs, which ultimately leads to death in consequence of right ventricle …