Chronic obstructive pulmonary disease (COPD) is a heterogeneous lung condition
characterized by persistent respiratory symptoms and airflow limitation. While there are …

Extracellular cyclophilins (eCyps) A and B are chemotactic mediators in several illnesses in
which inflammation plays an important role such as diabetes and cardiovascular diseases …

KD025 is a ROCK2 inhibitor currently being tested in clinical trials for the treatment of fibrotic
lung diseases. The therapeutic effects of KD025 are partly due to its inhibition of profibrotic …

A synergy between the rumen microbiota and the host genetics has created a symbiotic
relationship, beneficial to the host's health. In this study, the association between the host …

Cerebral cavernous malformations (CCM) are developmental venous dysplasias which
present as abnormally dilated blood vessels occurring mainly in the brain. Alterations in …

Transendothelial leukocyte migration is an early event in the progression of vascular
inflammation, the underlying molecular mechanism of atherosclerosis. Inflammatory …

Background Chronic obstructive pulmonary disease (COPD) exacerbations are
heterogenous and profoundly impact the disease trajectory. Bioactive lipid lysophosphatidic …

Objectives Atherosclerosis (AS) is a chronic inflammatory disease of the arterial wall, in
which Human Vascular Smooth Muscle Cells (HVSMCs) are involved. Nevertheless, the …

Aims Stroke is a devastating event and a huge public health concern worldwide. Apremilast
(APR) is a selective inhibitor of phosphodiesterase‐4 involved in various neurological …

Alzheimer's disease, characterized by amyloid beta peptides and neurofibrillary tangles, is
the most prevalent cause of dementia. Nowadays, some novel medicines being developed …