Introduction Asthma is a chronic lung disease influenced by environmental and inflammatory
triggers and involving complex signaling pathways across resident airway cells such as …

Neutrophilic asthma, as corticosteroid resistant asthma, is clinically more severe than
eosinophilic asthma. Therefore, the treatment of neutrophilic asthma has been a …

Isolated airway smooth muscle has been extensively investigated since 1840 to understand
the pharmacology of airway diseases. There has often been poor predictability from murine …

As a chronic respiratory disease, asthma is related to airway inflammation and remodeling.
Macrophages are regarded as main innate immune cells in the airway that exert various …

Asthma is a complex and heterogenous disease affected by a multitude of factors. Several
phenotypes of asthma exist which are influenced by various molecular mechanisms that …

Severe equine asthma (SEA) is a complex respiratory condition characterized by chronic
airway inflammation. It shares many clinical and pathological features with human …

Purpose Inhaled corticosteroids, including budesonide (BUD), are widely employed for the
treatment of asthma. However, the frequent use of corticosteroids is associated with …

The respiratory barrier, a thin epithelial barrier that separates the interior of the human body
from the environment, is easily damaged by toxicants, and chronic respiratory diseases are …

Epigenetic alterations such as dysregulation of miRNAs have been reported to play
important roles in interactions between genetic and environmental factors. In this study, we …

Neutrophilic asthma is generally defined by poorly controlled symptoms and high levels of
neutrophils in the lungs. Short-chain fatty acids (SCFAs) are proposed as …