Abstract Interleukin (IL)-11 evolved as part of the innate immune response. In the human
lung, IL-11 upregulation has been associated with viral infections and a range of …

Abstract Interleukin-11 (IL-11) is a cytokine that has been strongly implicated in the
pathogenesis of fibrotic diseases and solid malignancies. Elevated IL-11 expression is also …

Osteoarthritis causes pain and functional disability for over 500 million people worldwide. To
develop disease-stratifying tools and modifying therapies, we need a better understanding …

When small proteins such as cytokines bind to their associated receptors on the plasma
membrane, they can activate multiple internal signaling cascades allowing information from …

Aims This study aimed to elucidate the role of Interleukin-11 (IL-11) in hepatic fibrosis (HF)
and its potential as a therapeutic target for HF treatment. Materials and methods We …

As the anti-vaccination movement is spreading around the world, this paper addresses the
ever more urgent need for health professionals, communicators and policy-makers to grasp …

Interstitial lung disease (ILD) is one of the most serious extra-articular complications of
rheumatoid arthritis (RA), which increases the mortality of RA. Because the pathogenesis of …

Orbital fibrosis is a hallmark of tissue remodeling in thyroid-associated ophthalmopathy
(TAO). Previous studies have shown that interleukin (IL)-11 plays a pivotal profibrotic role in …

Cranial sutures are dynamic structures in which stem cell biology, bone formation, and
mechanical forces interface, influencing the shape of the skull throughout development and …

Bone metastases represent the main problem related to the progression of breast cancer, as
they are the main cause of death for these patients. Unfortunately, to date, bone metastases …