Advances in the technologies and informatics used to generate and process large biological
data sets (omics data) are promoting a critical shift in the study of biomedical sciences. While …

Sequence-specific transcription factors (TFs) regulate gene expression by binding to cis-
regulatory elements in promoter and enhancer DNA. While studies of TF–DNA binding have …

Abstract g: Profiler is a reliable and up-to-date functional enrichment analysis tool that
supports various evidence types, identifier types and organisms. The toolset integrates many …

Transcription factors (TFs) are proteins that interact with specific DNA sequences to regulate
gene expression and play crucial roles in all kinds of biological processes. To keep up with …

Abstract Knowledge of therapeutic targets and early drug candidates is useful for improved
drug discovery. In particular, information about target regulators and the patented …

The transcriptomic classification of glioblastoma (GBM) has failed to predict survival and
therapeutic vulnerabilities. A computational approach for unbiased identification of core …

Functional enrichment analysis is a key step in interpreting gene lists discovered in diverse
high-throughput experiments. g: Profiler studies flat and ranked gene lists and finds …

Transcription factors (TFs) are sequence-specific DNA-binding proteins acting as critical
regulators of gene expression. The Plant P romoter A nalysis N avigator (PlantPAN; …

PRODORIC is worldwide one of the largest collections of prokaryotic transcription factor
binding sites from multiple bacterial sources with corresponding interpretation and …

Abstract Models of transcription factor (TF) binding sites provide a basis for a wide spectrum
of studies in regulatory genomics, from reconstruction of regulatory networks to functional …