Pulmonary delivery of nanomedicines is very promising in lung local disease treatments
whereas several physiological barriers limit its application via the interaction with inhaled …

The pulmonary airways are continuously exposed to bacteria. As a first line of defense
against infection, the airway surface liquid (ASL) contains a complex mixture of antimicrobial …

The details of how a mucus hydrogel forms from its primary structural component, mucin
polymers, remain incompletely resolved. To explore this, we use a combination of …

Cystic fibrosis (CF) is a life-limiting disease characterised by recurrent respiratory infections,
inflammation and lung damage. The volume and composition of the airway surface liquid …

Cystic fibrosis (CF) is a recessive genetic disease that is characterised by airway mucus
plugging and reduced mucus clearance. There are currently alternative hypotheses that …

In utero, fetal lung epithelial cells actively secrete Cl− ions into the lung air spaces while Na+
ions follow passively to maintain electroneutrality. This process, driven by an …

Loss-of-function mutations in the cystic fibrosis transmembrane conductance regulator
(CFTR) compromise epithelial HCO3− and Cl− secretion, reduce airway surface liquid pH …

Antimicrobial peptides (AMPs) are potent antibiotics of the innate immune system that have
been extensively investigated as a potential solution to the global problem of infectious …

Modulation of airway surface liquid (ASL) pH has been proposed as a therapy for cystic
fibrosis (CF). However, evidence that ASL pH is reduced in CF is limited and conflicting. The …

Pseudomonas aeruginosa is the most prevalent bacterial species that contribute to cystic
fibrosis (CF) respiratory failure. The impaired function of CF transmembrane conductance …