Background Cystic fibrosis (CF, mucoviscidosis) is caused by mutations in the gene
encoding CF transmembrane conductance regulator (CFTR), which is a chloride and …

Biofilms are communities of microbes embedded in a matrix of extracellular polymeric
substances, largely polysaccharides. Multiple types of extracellular polymeric substances …

Cystic fibrosis (CF) is caused by defective Cystic Fibrosis Transmembrane Conductance
Regulator (CFTR) protein. Morbidity is mainly due to early airway infection. We hypothesized …

Mucosal administration of drugs and drug delivery systems has gained increasing interest.
However, nanoparticles intended to protect and deliver drugs to epithelial surfaces require …

The cystic fibrosis (CF) lung disease is due to the lack/dysfunction of the CF Transmembrane
Conductance Regulator (CFTR), a chloride channel expressed by epithelial cells as the …

Simulating native mucus with model systems such as gels made from reconstituted mucin or
commercially available polymers presents experimental advantages including greater …

The gene that encodes for the cystic fibrosis transmembrane regulator protein (CFTR) was
identified in 1989, yet major pathophysiologic questions remain unanswered. There is …

Introduction: Cystic fibrosis is an autosomal recessive disorder caused by mutations in the
cystic fibrosis transmembrane conductance regulator (CFTR) gene that codes for the CFTR …

The development of cystic fibrosis-related diabetes (CFRD) often leads to poorer outcomes
in patients with cystic fibrosis including increases in pulmonary exacerbations, poorer lung …

Nitric oxide (NO) is a broad-spectrum antibacterial agent, making it an attractive alternative
to traditional antibiotics for treating infections. To date, a direct comparison of the …