Proton secretion mediated by ATP12A protein on the surface of the airway epithelium may
contribute to cystic fibrosis (CF) lung disease by favoring bacterial infection and airway …

The cystic fibrosis (CF) airway surface liquid (ASL) provides a nutrient rich environment for
bacterial growth including elevated glucose, which together with defective bacterial killing …

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) ion channel
are established as the primary causative factor in the devastating lung disease cystic fibrosis …

A study has been carried out of the volatile organic compounds present in the exhaled
breath of 58 cystic fibrosis (CF) patients. An important observation is that the acetic acid …

Rationale: In cystic fibrosis (CF) a reduction in airway surface liquid (ASL) height
compromises mucociliary clearance, favoring mucus plugging and chronic bacterial …

The biomedical use of nanoparticles (NPs) has been the focus of intense research for over a
decade. As most NPs are explored as carriers to alter the biodistribution, pharmacokinetics …

Orai1 is a plasma membrane Ca2+ channel that mediates store-operated Ca2+ entry
(SOCE) and regulates inflammation. Short palate lung and nasal epithelial clone 1 …

Rationale: In cystic fibrosis the major cause of morbidity and mortality is lung disease
characterized by inflammation and infection. The influence of sphingolipid metabolism is …

The fluid covering the surface of airway epithelia represents a first barrier against
pathogens. The chemical and physical properties of the airway surface fluid are controlled …

Objectives Chronic infections with the opportunistic pathogen Pseudomonas aeruginosa are
responsible for the majority of the morbidity and mortality in patients with cystic fibrosis (CF) …