Tubular lipid binding proteins (TULIPs) have become a focus of interest in the cell biology of
lipid signalling, lipid traffic and membrane contact sites. Each tubular domain has an internal …

Bactericidal/permeability-increasing protein fold–containing family member A1 (BPIFA1),
formerly known as SPLUNC1, is one of the most abundant proteins in respiratory secretions …

Rationale: Cystic fibrosis (CF) lung disease is caused by the loss of function of the cystic
fibrosis transmembrane conductance regulator (CFTR) combined with hyperactivation of the …

Asthma is a chronic airway disease characterized by inflammation, mucus hypersecretion
and abnormal airway smooth muscle (ASM) contraction. Bacterial permeability family …

Cystic fibrosis is a lethal genetic disorder characterized by viscous mucus and bacterial
colonization of the airways. Airway surface liquid represents a first line of pulmonary …

Abstract Purpose of Review Biofilm represents an organized structure of microorganisms
within an extracellular matrix attached to a surface. While the importance of biofilm in …

Our understanding of mammalian–microbial mutualism has expanded by combing microbial
sequencing with evolving molecular and cellular methods, as well as unique model systems …

After more than two decades since clinical trials tested the first use of recombinant adeno-
associated virus (rAAV) to treat cystic fibrosis (CF) lung disease, gene therapy for this …

Abstract Background Cystic Fibrosis (CF) is an autosomal recessive disorder with life-
threatening organ manifestations. 87% of CF patients develop exocrine pancreas …

The multi-organ disease cystic fibrosis (CF) is caused by mutations in the cystic fibrosis
transmembrane regulator gene (CFTR) that lead to diminished transepithelial anion …