Mucociliary transport in healthy and cystic fibrosis pig airways
Y Xie, L Ostedgaard, MH Abou Alaiwa, L Lu… - Annals of the …, 2018 - atsjournals.org
Cystic fibrosis (CF) lung disease is the major cause of morbidity and mortality in people with
CF. Abnormal mucociliary transport has been the leading hypothesis for the underlying …
CF. Abnormal mucociliary transport has been the leading hypothesis for the underlying …
Infection, Allergy, and Inflammation: The Role of Aspergillus fumigatus in Cystic Fibrosis
TS Poore, ET Zemanick - Microorganisms, 2023 - mdpi.com
Aspergillus fumigatus (Af) is a mold frequently detected in airway samples from people with
cystic fibrosis (pwCF). Abnormal airway mucus may allow Af to germinate, resulting in airway …
cystic fibrosis (pwCF). Abnormal airway mucus may allow Af to germinate, resulting in airway …
[HTML][HTML] Repurposing tromethamine as inhaled therapy to treat CF airway disease
MH Abou Alaiwa, JL Launspach, KA Sheets… - JCI insight, 2016 - ncbi.nlm.nih.gov
In cystic fibrosis (CF), loss of CF transmembrane conductance regulator (CFTR) anion
channel activity causes airway surface liquid (ASL) pH to become acidic, which impairs …
channel activity causes airway surface liquid (ASL) pH to become acidic, which impairs …
[HTML][HTML] Ivacaftor-induced sweat chloride reductions correlate with increases in airway surface liquid pH in cystic fibrosis
MH Abou Alaiwa, JL Launspach, B Grogan, S Carter… - JCI insight, 2018 - ncbi.nlm.nih.gov
BACKGROUND. Disruption of cystic fibrosis transmembrane conductance regulator (CFTR)
anion channel function causes cystic fibrosis (CF), and lung disease produces most of the …
anion channel function causes cystic fibrosis (CF), and lung disease produces most of the …
Early pulmonary inflammation and lung damage in children with cystic fibrosis
Individuals with cystic fibrosis (CF) suffer progressive airway inflammation, infection and
lung damage. Airway inflammation and infection are present from early in life, often before …
lung damage. Airway inflammation and infection are present from early in life, often before …
Cystic fibrosis respiratory tract salt concentration: an exploratory cohort study
SG Lapierre, M Phelippeau, C Hakimi, Q Didier… - Medicine, 2017 - journals.lww.com
In cystic fibrosis patients, electrolytic and osmolality imbalance secondary to cystic fibrosis
transmembrane conductance regulator mutations may impact on mucoid secretion …
transmembrane conductance regulator mutations may impact on mucoid secretion …
Paracellular bicarbonate flux across human cystic fibrosis airway epithelia tempers changes in airway surface liquid pH
IM Thornell, T Rehman, AA Pezzulo… - The Journal of …, 2020 - Wiley Online Library
Key points Cl− and HCO3− had similar paracellular permeabilities in human airway
epithelia. PCl/PNa of airway epithelia was unaltered by pH 7.4 vs. pH 6.0 solutions. Under …
epithelia. PCl/PNa of airway epithelia was unaltered by pH 7.4 vs. pH 6.0 solutions. Under …
Cathepsin B contributes to Na+ hyperabsorption in cystic fibrosis airway epithelial cultures
CD Tan, C Hobbs, M Sameni, BF Sloane… - The Journal of …, 2014 - Wiley Online Library
Key points The epithelial Na+ channel (ENaC) is hyperactive in cystic fibrosis (CF) airway
epithelia, and contributes to excessive Na+ absorption and dehydration of the airway …
epithelia, and contributes to excessive Na+ absorption and dehydration of the airway …
An update on new and emerging therapies for cystic fibrosis
KM Hudock, JP Clancy - Expert opinion on emerging drugs, 2017 - Taylor & Francis
Introduction: Cystic fibrosis (CF) is a genetic disorder that results in a multi-organ disease
with progressive respiratory decline that ultimately leads to premature death. CF is caused …
with progressive respiratory decline that ultimately leads to premature death. CF is caused …
Extracellular pH and lung infections in cystic fibrosis
MM Massip-Copiz, TA Santa-Coloma - European journal of cell biology, 2018 - Elsevier
Cystic fibrosis (CF) is an autosomal recessive disease caused by CFTR mutations. It is
characterized by high NaCl concentration in sweat and the production of a thick and sticky …
characterized by high NaCl concentration in sweat and the production of a thick and sticky …