Mammalian short palate lung and nasal epithelial clone 1 (SPLUNC1) in pH-dependent airway hydration
R Tarran, MR Redinbo - The international journal of biochemistry & cell …, 2014 - Elsevier
The epithelia that line the conducting airways are the lung's first point of contact with inhaled
pathogens and toxicants. As such, they are known to play an important role in the lung's …
pathogens and toxicants. As such, they are known to play an important role in the lung's …
Antibacterial properties and efficacy of a novel SPLUNC1-derived antimicrobial peptide, α4-short, in a murine model of respiratory infection
Multidrug resistance (MDR) by bacterial pathogens constitutes a global health crisis, and
resistance to treatment displayed by biofilm-associated infections (eg, cystic fibrosis, surgical …
resistance to treatment displayed by biofilm-associated infections (eg, cystic fibrosis, surgical …
A Proteomics Investigation of Salivary Profiles as Potential Biomarkers for Autism Spectrum Disorder (ASD)
KL Wormwood, L Charette, JP Ryan, CC Darie… - The Protein …, 2023 - Springer
Abstract Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that affects
approximately 1/68 children, with a more recent study suggesting numbers as high as 1/36 …
approximately 1/68 children, with a more recent study suggesting numbers as high as 1/36 …
[HTML][HTML] The buffer capacity of airway epithelial secretions
D Kim, J Liao, JW Hanrahan - Frontiers in physiology, 2014 - frontiersin.org
The pH of airway epithelial secretions influences bacterial killing and mucus properties and
is reduced by acidic pollutants, gastric reflux, and respiratory diseases such as cystic fibrosis …
is reduced by acidic pollutants, gastric reflux, and respiratory diseases such as cystic fibrosis …
Acidosis exacerbates in vivo IL-1-dependent inflammatory responses and neutrophil recruitment during pulmonary Pseudomonas aeruginosa infection
IM Torres, YR Patankar… - American Journal of …, 2018 - journals.physiology.org
Acidic microenvironments commonly occur at sites of inflammation and bacterial infections.
In the context of a Pseudomonas aeruginosa infection, we previously demonstrated that …
In the context of a Pseudomonas aeruginosa infection, we previously demonstrated that …
Polymorphisms associated with expression of BPIFA1/BPIFB1 and lung disease severity in cystic fibrosis
BPI fold containing family A, member 1 (BPIFA1) and BPIFB1 are putative innate immune
molecules expressed in the upper airways. Because of their hypothesized roles in airway …
molecules expressed in the upper airways. Because of their hypothesized roles in airway …
[HTML][HTML] Esomeprazole increases airway surface liquid pH in primary cystic fibrosis epithelial cells
Respiratory failure, driven by airways mucus obstruction, chronic inflammation and bacterial
infections, is the main cause of mortality and morbidity in people with cystic fibrosis (CF) due …
infections, is the main cause of mortality and morbidity in people with cystic fibrosis (CF) due …
[HTML][HTML] Cell-free protein synthesis and in situ immobilization of deGFP-MatB in polymer microgels for malonate-to-malonyl CoA conversion
T Köhler, T Heida, S Hoefgen, N Weigel, V Valiante… - RSC …, 2020 - pubs.rsc.org
In the present work, microgels were utilized as a cell-free reaction environment to produce a
functional malonyl-CoA synthetase (deGFP-MatB) under geometry-controlled transcription …
functional malonyl-CoA synthetase (deGFP-MatB) under geometry-controlled transcription …
[HTML][HTML] Putting bicarbonate on the spot: pharmacological insights for CFTR correction in the airway epithelium
M Zajac, A Lepissier, E Dréano, B Chevalier… - Frontiers in …, 2023 - frontiersin.org
Introduction: Cystic fibrosis (CF) is caused by defective Cystic Fibrosis Transmembrane
Conductance Regulator (CFTR) proteins. CFTR controls chloride (Cl−) and bicarbonate …
Conductance Regulator (CFTR) proteins. CFTR controls chloride (Cl−) and bicarbonate …
c-Src and its role in cystic fibrosis
MMM Copiz, TA Santa Coloma - European journal of cell biology, 2016 - Elsevier
Cystic fibrosis (CF) is a lethal inherited disease produced by mutations in the gene encoding
the CFTR chloride channel. Loss of function in the CFTR gene is associated with a not much …
the CFTR chloride channel. Loss of function in the CFTR gene is associated with a not much …