The Roadmap toward Personalized Medicine: Challenges and Opportunities

C Cinti, MG Trivella, M Joulie, H Ayoub… - Journal of Personalized …, 2024 - mdpi.com
In 2019, the International Consortium for Personalised Medicine (ICPerMed) developed a
vision on how the use of personalized medicine (PM) approaches will promote “next …

Construction of a Tm-Value Prediction Model and Molecular Dynamics Study of AmNA-Containing Gapmer Antisense Oligonucleotide

M Kuroda, Y Kasahara, M Hirose, H Yamaguma… - … Therapy-Nucleic Acids, 2024 - cell.com
RNase H-dependent antisense oligonucleotides (gapmer ASOs) represent a class of nucleic
acid therapeutics that bind to target RNA to facilitate RNase H-mediated RNA cleavage …

Versatile Strategies of Nucleic Acid Synthesis for Rational Design and Biomedical Applications

Y AKIYAMA - Nano Biomedicine, 2024 - jstage.jst.go.jp
Nucleic acids, serving as both a repository for genetic information and the basis for
biological activity, can be regarded as highly ordered functional molecules. Oligonucleotides …