Bronchodilators remain the cornerstone of the treatment of airway disorders such as asthma
and chronic obstructive pulmonary disease (COPD). There is therefore considerable interest …

It is now established that airway smooth muscle (ASM) has roles in determining airway
structure and function, well beyond that as the major contractile element. Indeed, changes in …

Airway structure and function are key aspects of normal lung development, growth, and
aging, as well as of lung responses to the environment and the pathophysiology of important …

A main goal of regenerative medicine is to replace lost or damaged tissues and organs with
functional parts of the correct size and shape. But the proliferation of new cells is not …

Airway remodeling in asthma driven by inflammation involves proliferation of epithelial cells
and airway smooth muscle (ASM), as well as enhanced extracellular matrix (ECM) …

Long‐term exposure to cigarette smoke (CS) triggers airway hyperreactivity and remodeling,
effects that involve airway smooth muscle (ASM). We previously showed that CS …

Methods: We used primary human ASM cells from non-asthmatics vs. asthmatics to
determine AR expression at baseline and with inflammation measured using Western …

Recent studies have demonstrated an effect of neurotrophins, particularly brain-derived
neurotrophic factor (BDNF), on airway contractility [via increased airway smooth muscle …

Background The molecular mechanisms responsible for airway smooth muscle
cells'(aSMCs) contraction and proliferation in airway hyperresponsiveness (AHR) …

Airway smooth muscle (ASM) cell dysfunction is an important component of several
obstructive pulmonary diseases, particularly asthma. External stimuli such as allergens …