Heterogeneous intracellular pathways and biochemical mechanisms are responsible for
generating the glycoprotein complexes of peptide and major histocompatibility complex that …

Peptide‐bond isosteres can enable a deep interrogation of the structure and function of a
peptide or protein by amplifying or attenuating particular chemical properties. In this …

Previous studies have attempted to define human leukocyte antigen (HLA) class II
supertypes, analogous to the case for class I, on the basis of shared peptide-binding motifs …

The fish immune system is a topic or subject that offers a unique understanding of defensive
system evolution in vertebrate heredity. While gut microbiota plays several roles in fish: well …

We report a one-step catalytic, enantioselective method for the preparation of homoallylic N-
Boc amines directly from acetals. Reactive iminium ion intermediates are generated in situ …

The presentation of peptide-MHCII complexes (pMHCIIs) for surveillance by T cells is a well-
known immunological concept in vertebrates, yet the conformational dynamics of antigen …

DM edits the peptide repertoire presented by major histocompatibility complex class II
molecules by professional antigen-presenting cells (APCs), favoring presentation of some …

The peptide editor HLA-DM (DM) mediates exchange of peptides bound to major
histocompatibility (MHC) class II molecules during antigen processing; however, the …

Major histocompatibility complex (MHC) class I and II proteins have been in the focus of
interest for immunologists, biochemists, cell biologists, and structural biologists for decades …

The neuronal-voltage gated sodium channel (VGSC), NaV1. 6, plays an important role in
propagating action potentials along myelinated axons. Calmodulin (CaM) is known to …