Immunotherapy is leading a paradigm shift in the treatment of various diseases, including
tumors, auto‐immune diseases, and infectious diseases. However, the limited response rate …

Infections in critically ill patients are associated with persistently poor clinical outcomes.
These patients have severely altered and variable antibiotic pharmacokinetics and are …

Sepsis, a condition caused by severe infections, affects more than 30 million people
worldwide every year and remains the leading cause of death in hospitals,. Moreover …

Objective: To discuss the altered pharmacokinetic properties of selected antibiotics in
critically ill patients and to develop basic dose adjustment principles for this patient …

Novel strategies for the treatment of sepsis | Nature Medicine Skip to main content Thank you
for visiting nature.com. You are using a browser version with limited support for CSS. To …

Sepsis was first described by the ancient Greek physicians over 2000 years ago. The
pathophysiology of the disease, however, is still not fully understood and hence the mortality …

Frequently used experimental models of sepsis include cecal ligation and puncture,
ascending colon stent peritonitis, and the ip or iv injection of bacteria or bacterial products …

Purpose An understanding of the pharmacokinetic (PK) and pharmacodynamic (PD)
principles that determine response to antimicrobial therapy can provide the clinician with …

Mera S, Tatulescu D, Cismaru C, Bondor C, Slavcovici A, Zanc V, Carstina D, Oltean M.
Multiplex cytokine profiling in patients with sepsis. APMIS 2010; 119: 155–63. A major goal …

Introduction Impaired T cell function in sepsis is associated with poor outcome, but the
mechanisms are unclear. In cancer, arginase-expressing myeloid derived suppressor cells …