Metabolomics as a research field and a set of techniques is to study the entire small
molecules in biological samples. Metabolomics is emerging as a powerful tool generally for …

Mounting evidence has shown that gut microbiome is associated with various cancers,
including gastrointestinal (GI) tract and non-GI tract cancers. But microbiome data have …

Herein we gathered updated knowledge regarding the alterations of gut microbiota
(dysbiosis) and its correlation with human neurodegenerative and brain-related diseases …

Since advances in next-generation sequencing (NGS) technique enabled to investigate
uncultured microbiota and their genomes in unbiased manner, many microbiome …

Objective Approximately 24–68% of breast cancer survivors report co-occurring
psychoneurological symptoms of pain, fatigue, sleep disturbance, depression, and anxiety …

This chapter focuses on compositional data analysis (CoDA). First, it describes overall
compositional data, the rationale that microbiome data can be treated as compositional …

Chapter 9 investigated within-sample (alpha-) diversity. This chapter focuses on between-
sample (beta-) diversity metrics and their ordination. Beta diversity measures the difference …

Chapter 15 mainly introduced the glmmTMB, GLMMadaptive, and FZINBMM packages.
However, all these three packages can only analyze univariate longitudinal microbiome …

This chapter investigates the movement of moving beyond OTU methods and discusses the
necessity and possibility of this movement. First, it describes clustering-based OTU methods …

This chapter investigates the original OTU methods in numerical taxonomy. First, it briefly
introduces the history of numerical taxonomy. Second, it introduces the principles and aims …