Autism spectrum disorders (ASD) are diagnosed on the basis of three behavioral features
namely deficits in social communication, absence or delay in language, and stereotypy. The …

Preventing Mental, Emotional, and Behavioral Disorders Among Young People: Progress and
Possibilities | The National Academies Press Skip to main content Navigate to Help Ordering …

Epigenetic mechanisms such as DNA methylation and modifications to histone proteins
regulate high-order DNA structure and gene expression. Aberrant epigenetic mechanisms …

Dravet syndrome is a severe epileptic encephalopathy caused primarily by
haploinsufficiency of the SCN1A gene. Repetitive seizures can lead to endurable and …

MeCP2 is a reader of the DNA methylome that occupies a large proportion of the genome
due to its high abundance and the frequency of its target sites. It has been the subject of …

Autism is a common childhood neurodevelopmental disorder with strong genetic liability. It is
not a unitary entity but a clinical syndrome, with variable deficits in social behavior and …

Epigenetic mechanisms, such as DNA methylation, regulate transcriptional programs to
afford the genome flexibility in responding to developmental and environmental cues in …

Rett syndrome (RTT) is caused by mutations of MECP2, a methyl CpG binding protein
thought to act as a global transcriptional repressor. Here we show, using an isogenic human …

Current epigenomics approaches have facilitated the genome-wide identification of
regulatory elements based on chromatin features and transcriptional regulator binding and …

Rett Syndrome (RTT) is a severe form of X-linked mental retardation caused by mutations in
the gene coding for methyl CpG-binding protein 2 (MECP2). Mice deficient in MeCP2 have a …