The transforming growth factor-β (TGF-β) system signals via protein kinase receptors and
SMAD mediators to regulate a large number of biological processes. Alterations of the TGF …

The TGF-β (transforming growth factor-β) system signals via protein kinase receptors and
Smad mediators to regulate a plethora of biological processes, including morphogenesis …

Activins are dimeric glycoproteins belonging to the transforming growth factor beta
superfamily and resulting from the assembly of two beta subunits, which may also be …

Granulosa cell tumors of the ovary (GCT) comprise a distinct subset of ovarian cancers that
account for approximately 5% of all ovarian malignancies. They are thought to arise from …

Betaglycan is a co-receptor for the TGFβ superfamily, particularly important in establishing
the potency of its ligands on their target cells. In recent years, new insights have been …

The anterior pituitary gland has the ability to respond to complex signals derived from central
and peripheral systems. Perception of these signals and their integration are mediated by …

Background Bone is one of the most frequent metastatic sites of advanced breast cancer.
Current therapeutic agents aim to inhibit osteoclast-mediated bone resorption but only have …

In mammals, members of the transforming growth factor-beta (TGF-β) superfamily are known
to have key roles in the regulation of follicular growth and development. The aim of the study …

Osteosarcoma (OS) is the most common pediatric malignant bone tumor, and occurrence of
pulmonary metastasis generally causes a rapid and fatal outcome. Here we aimed to …

We previously reported that activin produces a signal with a tumor suppressive role in
pancreatic cancer (PC). Here, the association between plasma activin A and survival in …