Studies have reported a positive correlation between elevated CD8+ T cells in the tumor
microenvironment (TME) and good prognosis in cancer. However, the mechanisms linking T …

T cell dysfunction in solid tumors results from multiple mechanisms. Altered signaling
pathways in tumor cells help produce a suppressive tumor microenvironment enriched for …

The immune system plays a vital role in suppressing tumor cell progression. The tumor
microenvironment augmented with significant levels of tumor-infiltrating lymphocytes has …

Calorie restriction (CR) extends lifespan and has been shown to reduce age-related
diseases including cancer, diabetes, and cardiovascular and neurodegenerative diseases …

Cell senescence is a driver of ageing, frailty, age-associated disease and functional decline.
In oncology, tumour cell senescence may contribute to the effect of adjuvant therapies, as it …

Excess body fat is a major risk factor for endometrial cancer incidence, but its impact on
recurrence and survival remains unclear. The aim of this systematic review and meta …

One in eight women will develop breast cancer over their lifetime making it the most
common female cancer. The cause of breast cancer is multifactorial and includes hormonal …

Background: Metabolic syndrome is a combination of dysregulated cardiometabolic risk
factors characterized by dyslipidemia, impaired glucose tolerance, insulin resistance …

Breast cancer is the second highest prevalent cancer globally after lung cancer with 2.09
million cases during 2018. Adults about 1.9 billion were overweight and over 650 million out …

Obesity is a major risk factor for cancer. Conventional thought suggests that elevated
adiposity predisposes to heightened inflammatory stress and potentiates tumor growth, yet …