[HTML][HTML] Towards an understanding of synapse formation
TC Südhof - Neuron, 2018 - cell.com
Synapses are intercellular junctions specialized for fast, point-to-point information transfer
from a presynaptic neuron to a postsynaptic cell. At a synapse, a presynaptic terminal …
from a presynaptic neuron to a postsynaptic cell. At a synapse, a presynaptic terminal …
[HTML][HTML] DREADDs for neuroscientists
BL Roth - Neuron, 2016 - cell.com
To understand brain function, it is essential that we discover how cellular signaling specifies
normal and pathological brain function. In this regard, chemogenetic technologies represent …
normal and pathological brain function. In this regard, chemogenetic technologies represent …
[HTML][HTML] LTP induction by structural rather than enzymatic functions of CaMKII
JE Tullis, ME Larsen, NL Rumian, RK Freund… - Nature, 2023 - nature.com
Learning and memory are thought to require hippocampal long-term potentiation (LTP), and
one of the few central dogmas of molecular neuroscience that has stood undisputed for …
one of the few central dogmas of molecular neuroscience that has stood undisputed for …
Conformational states dynamically populated by a kinase determine its function
INTRODUCTION Protein kinases mediate many cell signaling processes. Central to their
physiological function is the regulation of their binding and enzymatic activities, which is …
physiological function is the regulation of their binding and enzymatic activities, which is …
Unleashing the power of bond cleavage chemistry in living systems
Bioorthogonal cleavage chemistry has been rapidly emerging as a powerful tool for
manipulation and gain-of-function studies of biomolecules in living systems. While the initial …
manipulation and gain-of-function studies of biomolecules in living systems. While the initial …
Targeting transcription cycles in cancer
SJ Vervoort, JR Devlin, N Kwiatkowski, M Teng… - Nature Reviews …, 2022 - nature.com
Accurate control of gene expression is essential for normal development and dysregulation
of transcription underpins cancer onset and progression. Similar to cell cycle regulation …
of transcription underpins cancer onset and progression. Similar to cell cycle regulation …
Protein phosphorylation: a major switch mechanism for metabolic regulation
Metabolism research is undergoing a renaissance because many diseases are increasingly
recognized as being characterized by perturbations in intracellular metabolic regulation …
recognized as being characterized by perturbations in intracellular metabolic regulation …
[HTML][HTML] mTORC1 controls phase separation and the biophysical properties of the cytoplasm by tuning crowding
Macromolecular crowding has a profound impact on reaction rates and the physical
properties of the cell interior, but the mechanisms that regulate crowding are poorly …
properties of the cell interior, but the mechanisms that regulate crowding are poorly …
[HTML][HTML] CDK substrate phosphorylation and ordering the cell cycle
S phase and mitotic onset are brought about by the action of multiple different cyclin-CDK
complexes. However, it has been suggested that changes in the total level of CDK kinase …
complexes. However, it has been suggested that changes in the total level of CDK kinase …
[HTML][HTML] Status of large-scale analysis of post-translational modifications by mass spectrometry
Cellular function can be controlled through the gene expression program, but often protein
post-translational modifications (PTMs) provide a more precise and elegant mechanism. Key …
post-translational modifications (PTMs) provide a more precise and elegant mechanism. Key …