Amyotrophic lateral sclerosis (ALS) is a neurodegenerative condition noteworthy for upper
and lower motor neuron death. Involvement of respiratory motor neuron pools leads to …

The provision of mechanical insufflation-exsufflation (MI-E) devices to enhance cough
efficacy is increasing. Typically, MI-E devices are used to augment cough in patients with …

Background Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease
characterized by progressive diaphragm weakness and deteriorating lung function. Bulbar …

Long-term mechanical ventilation is a well-established treatment for chronic hypercapnic
respiratory failure (CHRF). It is aimed at improving CHRF-related symptoms, health-related …

When the ability to cough is impaired, secretion clearance may be assisted and augmented
with mechanical insufflation-exsufflation (MI-E). In some individuals, the efficacy of MI-E may …

Mechanical insufflation-exsufflation (MI-E) is traditionally used in the neuromuscular
population. There is growing interest of MI-E use in invasively ventilated critically ill adults …

Background Respiratory muscle weakness can impair cough function, leading to lower
respiratory tract infections. These infections are an important contributor to morbidity and …

Children with neuromuscular, chronic neurologic, and chest wall diseases are at increased
risk of postoperative respiratory complications including atelectasis, pneumonia, and …

Objectives Swallow and cough dysfunction are possible surgical complications of lung
transplantation (LT). We examined voluntary cough strength, sensorimotor reflexive cough …

Cough is an important mechanism of airway clearance. In patients who present weak and
ineffective cough, augmentation techniques aim to assist or simulate the maneuver. These …