Background Decline in mitochondrial function occurs with aging and may increase mortality.
We discuss mitochondrial contribution to Covid-19 sepsis, specifically the complex …

Host excessive inflammatory immune response to SARS-CoV-2 infection is thought to
underpin the pathogenesis of COVID-19 associated severe pneumonitis and acute lung …

The past few decades have witnessed significant progress in the discovery of hydrogen
sulfide (H 2 S) as a ubiquitous gaseous signaling molecule in mammalian physiology, akin …

Obesity, a complex disease involving an excessive amount of body fat and a major threat to
public health all over the world, is the determining factor of the onset and development of …

Non-alcoholic fatty liver disease (NAFLD), or metabolic (dysfunction)-associated fatty liver
disease (MAFLD), is characterized by high global incidence and prevalence, a tight …

Cellular homeostasis in eukaryotic cells requires synchronized coordination of multiple
organelles. A key role in this stage is played by mitochondria, which have recently emerged …

Exaggerated oxidative stress and hyper-inflammation are essential features of
oxidative/inflammatory diseases. Simultaneously, both processes may be the cause or …

Coronaviruses encode a variable number of accessory proteins that are involved in host-
virus interaction, suppression of immune responses, or immune evasion. SARS-CoV-2 …

Our study aims at developing knowledge-based strategies minimizing chronic changes in
the brain after severe spinal cord injury (SCI). The SCI-induced long-term metabolic …

Background Acute lung injury is an important factor that leads to the death of patients with
pneumonia. Previous studies have shown that nicotinamide (NAM) plays a role in reducing …