Context Cisplatin, a coordination platinum complex, is used as a potential anti-neoplastic
agent, having well recognized DNA-damaging property that triggers cell-cycle arrest and cell …

Inflammatory processes are involved in the pathogenesis of diabetic nephropathy. The aim
of this study was to clarify the role of mitogen-activated protein kinase (MAPK) pathways for …

IgA nephropathy (IgAN) is the most common primary glomerular disease in China. Primary
infections always occur before IgAN. However, the pathology of IgAN is still unclear …

Apoptosis signal‐regulating kinase 1 (ASK1) is a member of the mitogen‐activated protein
kinase (MAP3K) family which acts as an upstream regulator for the activation of p38 MAPK …

Peritoneal fibrosis is a complication of patients with long-term continuous ambulatory
peritoneal dialysis (CAPD). Reports have indicated that angiotensin (Ang) II may correlate …

In this study we examine changes in the cellular properties of FRTL-5 cells as a function of
passage number, with particular emphasis on gap junction expression, karyotype …

Diabetic nephropathy (DN) is a serious complication of diabetes with a poorly defined
etiology and limited treatment options. Early intervention is a key to preventing the …

Microtubule-associated protein tau, an integral component of neurofibrillary tangles,
interacts with a variety of signaling molecules. Previously, our laboratory reported that nerve …

Abstract Sterile 20/SPS1-related proline/alanine-rich kinase (SPAK) can stimulate
production of proinflammatory cytokines and interact with inflammation-related molecules …

Introduction Kidney injury is clinically classified as crescentic glomerulonephritis (CrGN)
when≥ 50% of the glomeruli in a biopsy sample contain crescentic lesions. However …