BACKGROUND: Obesity and diabetes are significant risk factors for the development and
progression of renal disease. Loss of podocytes, the glomerular epithelial cells that maintain …

Background: Glomerular diseases encompass a group of kidney diseases that may share
common gene expression pathways. We aimed to analyze glomerular-specific gene …

In salivary glands, epithelial cells perform functional activities such as the production and
secretion of saliva. Therefore, the use of salivary gland epithelial cells to study general …

ACE angiotenzin konvertáló enzim AP-1 aktivátor fehérje 1 ARB angiotenzin receptor
blokkolók BMP-7 csont morfogenikus fehérje-7 (Bone morphogenic protein-7) CKD krónikus …

目的研究exendin-4 对高糖培养大鼠肾小球系膜细胞(GMCs) 细胞外基质分泌的影响及相关机制
. 方法体外培养GMCs, 分为4 组: 正常对照组(NC 组), 正常对照+ exendin-4 组(NCE 组) …

abstract In this Letter we describe the discovery of potent, selective, and orally active
aminopurine JNK inhibitors. Improving the physico-chemical properties as well as …

Acute kidney injury induced by cisplatin poses a serious health hazard to patients. Thus, this
study was undertaken to elucidate key signaling pathways and hub genes relevant for …

Polycystic kidney disease is an inherited degenerative disease in which the uriniferous
tubules are replaced by expanding fluid-filled cysts that ultimately destroy organ function …

Background/Aims: The c-Jun amino-terminal kinase (JNK) signaling pathway is activated in
human kidney diseases and promotes renal injury in experimental glomerulonephritis. In …

The disposition of tanzisertib [(1S, 4R)-4-(9-((S) tetrahydrofuran-3-yl)-8-(2, 4, 6-
trifluorophenyla-mino)-9H-purin-2-ylamino) cyclohexanol], a potent, orally active c-Jun …