[HTML][HTML] Comprehensive structural and molecular comparison of spike proteins of SARS-CoV-2, SARS-CoV and MERS-CoV, and their interactions with ACE2

MM Hatmal, W Alshaer, MAI Al-Hatamleh, M Hatmal… - Cells, 2020 - mdpi.com
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has recently emerged
in China and caused a disease called coronavirus disease 2019 (COVID-19). The virus …

Mutations in SARS-CoV-2; Consequences in structure, function, and pathogenicity of the virus

B Bakhshandeh, Z Jahanafrooz, A Abbasi, MB Goli… - Microbial …, 2021 - Elsevier
The third pandemic of coronavirus infection, called COVID-19 disease, began recently in
China. The newly discovered coronavirus, entitled SARS-CoV-2, is the seventh member of …

SARS-CoV-2–specific T cells are rapidly expanded for therapeutic use and target conserved regions of the membrane protein

MD Keller, KM Harris… - Blood, The Journal …, 2020 - ashpublications.org
T-cell responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have
been described in recovered patients, and may be important for immunity following infection …

[HTML][HTML] Drug targets for COVID-19 therapeutics: Ongoing global efforts

A Saxena - Journal of biosciences, 2020 - Springer
The current global pandemic COVID-19 caused by the SARS-CoV-2 virus has already
inflicted insurmountable damage both to the human lives and global economy. There is an …

[HTML][HTML] A comprehensive overview of the COVID-19 literature: machine learning–based bibliometric analysis

A Abd-Alrazaq, J Schneider, B Mifsud, T Alam… - Journal of medical …, 2021 - jmir.org
Background Shortly after the emergence of COVID-19, researchers rapidly mobilized to
study numerous aspects of the disease such as its evolution, clinical manifestations, effects …

Timeline of changes in spike conformational dynamics in emergent SARS-CoV-2 variants reveal progressive stabilization of trimer stalk with altered NTD dynamics

SM Braet, TSC Buckley, V Venkatakrishnan, KMA Dam… - Elife, 2023 - elifesciences.org
SARS-CoV-2 emergent variants are characterized by increased viral fitness and each shows
multiple mutations predominantly localized to the spike (S) protein. Here, amide …

[HTML][HTML] The effects of amino acid substitution of spike protein and genomic recombination on the evolution of SARS-CoV-2

L Fang, J Xu, Y Zhao, J Fan, J Shen, W Liu… - Frontiers in …, 2023 - frontiersin.org
Over three years' pandemic of 2019 novel coronavirus disease (COVID-19), multiple
variants and novel subvariants have emerged successively, outcompeted earlier variants …

[HTML][HTML] Current status of putative animal sources of SARS-CoV-2 infection in humans: wildlife, domestic animals and pets

M Maurin, F Fenollar, O Mediannikov, B Davoust… - Microorganisms, 2021 - mdpi.com
SARS-CoV-2 is currently considered to have emerged from a bat coronavirus reservoir.
However, the real natural cycle of this virus remains to be elucidated. Moreover, the COVID …

[HTML][HTML] An overview of viral mutagenesis and the impact on pathogenesis of SARS-CoV-2 variants

MZI Khan, A Nazli, H Al-Furas, MI Asad, I Ajmal… - Frontiers in …, 2022 - frontiersin.org
Viruses are submicroscopic, obligate intracellular parasites that carry either DNA or RNA as
their genome, protected by a capsid. Viruses are genetic entities that propagate by using the …

[HTML][HTML] The pathophysiology, diagnosis and treatment of corona virus disease 2019 (COVID-19)

SK Das - Indian Journal of Clinical Biochemistry, 2020 - Springer
Since the beginning of this century, beta coronaviruses (CoV) have caused three zoonotic
outbreaks. However, little is currently known about the biology of the newly emerged SARS …