The pharmacology, clinical efficacy and safety of new alpha-adrenergic receptor antagonists
for the treatment of hypertension was reviewed (Table XIV). Although all these agents block …

1 Isolated superior mesenteric veins from portal hypertensive rats were 3 to 10 times more
sensitive to 5‐hydroxytryptamine (5‐HT) and 3 times less sensitive to (‐)‐noradrenaline than …

The quinazolinedione derivative ketanserin was studied in many known and newly
introduced tests to obtain its detailed pharmacological profile. Ketanserin was a potent …

The ability of the putative serotonin 2 (5-HT 2) antagonist ketanserin, to alter serotonin (5-
HT)-induced responses in cell firing was examined in the prefrontal cortex, the lateral …

In vitro affinity for vascular 5HT2 and alpha receptors was determined for several
compounds (spiperone, ketanserin, mianserin, trazodone, mepiprazole, benzoctamine, m …

Blood pressure and heart rate, supine and standing, were studied in patients with essential
hypertension during 8 weeks of oral therapy with two dosage schedules of ketanserin, 40 …

Ketanserin is a new antihypertensive agent with affinity to serotonin (5-HT) 2 receptors and
at higher concentrations also to α 1-adrenoceptors. The present study was designed to …

Pirenperone, which is chemically related to ketanserin, has been reported to be a selective
serotonin 2 (5-HT 2) antagonist and a specific d-LSD antagonist. We now report that …

Novel 1, 5-benzoxathiepin derivatives, 3, 4-dihydro-2H-1, 5-benzoxathiepin-3-ols with an
aminoalkyl group at the 2-, 3-or 4-position, were synthesized and evaluated for serotonin S2 …

Ketanserin (120 mg/day) or placebo was given orally to 14 patients with mild to moderate
essential hypertension according to a double blind crossover protocol, each treatment …